In the main event, middleweight champion Israel Adesanya (23-1 MMA, 12-1 UFC) puts his title on the line against challenger Alex Pereira (6-1 MMA, 3-0 UFC), who holds two kickboxing wins over him. In the co-feature, women’s strawweight champion Carla Esparza (19-6 MMA, 10-4 UFC) defends the belt for the first time in her second stint as champ against former titleholder Zhang Weili (22-3 MMA, 6-2 UFC), who is a 4-1 favorite to reclaim the title. In addition, former Bellator champ Michael Chandler (23-7 MMA, 2-2 UFC) takes on former UFC interim titleholder Dustin Poirier (28-7 MMA, 20-6 UFC) in a key lightweight bout and former 155-pound champ Frankie Edgar (24-10-1 MMA, 18-10-1 UFC) fights for what is expected to be the final time when he meets Chris Gutierrez (18-3-2 MMA, 6-1-1 UFC) at bantamweight.
Follow along with our round-by-round updates and official results beginning at approximately 6 p.m. ET for the early prelims on ESPN+, 8 p.m. ET for the prelims on ESPNews and 10 p.m. ET for the main card on pay-per-view.
Adesanya is a -230 favorite (risk $230 to win $100), while Pereira comes back at +190 in the latest Caesars Sportsbook MMA odds for UFC 281: Adesanya vs. Pereira. In the co-main event, women's strawweight champion Carla Esparza (+280) defends her belt against former champion Zhang Weili (-360). Before settling any selections of your own for UFC 281: Adesanya vs. Pereira, make sure you check out the MMA predictions and betting advice from SportsLine expert Kyle Marley.
Marley won the first-ever "ToutMaster" UFC betting contest sponsored by MMAOddsBreaker and appears regularly on multiple MMA betting and daily Fantasy shows. He watches every single fight for every professional MMA card and does extensive research before each event.
Over the past three-plus years, $100 bettors who have followed Marley's picks are up more than $13,000. The accomplished MMA analyst kicked off the 2022 UFC season in January by advising SportsLine members to back Calvin Kattar (+200) against Giga Chikadze (-240) in the featherweight main event. Kattar's lopsided unanimous-decision victory gave Marley's followers another easy winner. Anyone who has followed him is way up.
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